A plasma potassium concentration of approximately 4mmol/L appeared to be needed for adequate urinary alkalization.

Urinary alkalization was not attempted during the first admission, which was associated with the longest apparent elimination half-life of salicylate (30 hours). On each occasion, he was given intravenous fluid with the aim of achieving euvolemia. A single dose of activated charcoal was administered only after the second overdose. This categorization was more consistent with the clinical severity of his admissions. However, as assessed by the observed salicylate concentrations, the ingestions would more appropriately have been categorized as being of “moderate” severity for the first and second overdose and “mild” severity for each of the others.

The overdoses were categorized as “potentially lethal” on two occasions and as “serious” in the other two, based on the alleged dose of aspirin ingested (over 500mg/kg in the first two overdoses, and 320mg/kg and 498mg/kg in the other two, respectively). During his third admission, he overdosed with aspirin, while on the ward recovering from the previous aspirin overdose. Case presentationĪ 75-year-old Caucasian man who weighed 45kg and had an extensive history of various drug overdoses and stage 3 chronic kidney disease presented to a tertiary university hospital on three occasions within 2 months after successive overdoses of aspirin. The case provided an unusual and possibly one-of-a-kind opportunity to focus on the variability in the time course of plasma salicylate concentrations with current treatment modalities of aspirin overdose in an individual patient. The patient described in this case report intentionally ingested overdoses of aspirin on repeated occasions. Aspirin overdose, though now infrequently encountered, nevertheless continues to contribute to significant morbidity and mortality.

Aspirin overdose antidote